By Nabil Hanna, Vincent A. Pollack, Isaiah J. Fidler (auth.), G. Bennett Humphrey M.D., Ph.D., Dr. Gerald B. Grindey, Dr. Louis P. Dehner, Ronald T. Acton Ph.D., Dr. Theodore J. Pysher (eds.)
, Adrenal and Endocrine Tumors in childrens' is the 3rd quantity within the sequence, 'Cancer remedy and study' dedicated to pediatric oncology. Like its predecessors, it truly is geared up into sections. the 1st part back bargains with problems with easy study germane to the certainty of early life malignancies. In quantity three, the scope of the 1st part has been broadened to incorporate a assessment that's epidemiologically orientated and a moment overview that's psychologically orientated. within the moment half, significant pediatric oncology devices in Japan, Australia, Europe and the Americas were invited to document their adventure with of the a number of endocrine adrenal cortical carcinomas and the presentation neoplasia syndromes in little ones. as well as those institutional experiences of case fabric, there are reports on genetics, pathology, and a diagnostic overview of kids. The evaluation bankruptcy on adrenal cortical carcinoma contains thoughts for radiotherapy from Dr. D' Angio and for che motherapy from Dr. Philip Schein. participants utilizing those prompt treatments are inspired to record their effects to the editors. The informa tion will then be made on hand to others on request. record of individuals ACTON, Dr. Ronald, Diabetes learn health facility, Room 817, 1808 seventh Ave. South, Birmingham, AL 35233, united states. BAUM, Edward S., M.D., department of Hematology/Oncology, Northwestern collage clinical college, kid's Memorial medical institution, 2300 baby ren's Plaza, Chicago, IL 60614, united states. BENZ, Dr. Chris c., Dept. of drugs, Yale collage institution of drugs, New Haven, CT 06510, USA.
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108. Schabel FM Jr: Concepts for systemic treatment of micrometastases. Cancer 35: 15-24, 1975. 109. Trope C, Hakansson L, Dencker H: Heterogeneity of human adenocarcinomas of the colon and the stomach as regards sensitivity to cytostatic drugs. Neoplasma 22: 423-430, 1975. 110. Trope C: Different sensitivity to cytostatic drugs of primary tumor and metastasis of the Lewis carcinoma. Neoplasma 22: 171-180, 1975. Ill. Hanna N, Burton RC: Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastasis in vivo.
In addition to the effects of these agents as radiation sensitizers, that is, increasing cell kill when present at the time of irradiation, the nitroimidazoles also possess other properties which must be considered in evaluating their clinical usefulness. Over extended exposure periods both in vitro and in vivo these agents can also kill hypoxic cells in the absence of irradiation. A possibly related effect is the reduction of the shoulder of radiation survival curves G. Bennett Humphrey et al.
In addition to producing cell killing, nitro-compounds may alter signifi- 27 cantly the oxygen consumption rate of cells . Generally nitro-compounds produce immediate inhibition or stimulation of cellular oxygen consumption. MISO, however, has essentially no immediate effect on oxygen consumption and inhibition of consumption only begins to occur under conditions of long exposure where toxicity also results . Other studies related to the redox state of the cell have demonstrated that oxidizing and reducing agents may modify the degree of hypoxic toxicity obtained with misonidazole.
Adrenal and Endocrine Tumors in Children: Adrenal Cortical Carcinoma and Multiple Endocrine Neoplasia by Nabil Hanna, Vincent A. Pollack, Isaiah J. Fidler (auth.), G. Bennett Humphrey M.D., Ph.D., Dr. Gerald B. Grindey, Dr. Louis P. Dehner, Ronald T. Acton Ph.D., Dr. Theodore J. Pysher (eds.)