By Eric T. Wong
This concise textual content presents an entire review of alternating electrical fields treatment -- often referred to as tumor treating fields -- for glioblastoma and different sorts of strong tumor malignancies. Readers are given a primary figuring out of this novel anti-cancer remedy modality by means of studying from scientific trial info in addition to the actual and telephone biology results on tumor cells whilst alternating electrical fields are utilized either in vitro and in vivo.
Chapters illustrate the physics in the back of electrical box propagation in area and different media. this can be by way of a evaluate of our present realizing of the electrical box results on dividing cells - together with the disruption of cytokinesis, right chromosome segregation and activation at the mobile floor chaperons that result in immunogenic cellphone dying. facts from part III trials for the therapy of recurrent and newly clinically determined glioblastomas are integrated, in addition to a few of the ancillary post hoc analyses that have been played via a variety of investigators. the rest of the bankruptcy covers different reliable tumor malignancies, together with non-small cellphone lung melanoma, pancreatic melanoma and ovarian melanoma, as this therapy modality is being utilized to systemic malignancies.
Alternating electrical Fields treatment in Oncology bargains oncologists, neurologists, radiation oncologists, biomedical engineers, mobilephone biologists and mitosis researchers the basics wanted for scientific practice.
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Additional info for Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields
B) Normalized maximal peak force values, plotted as functions of cell radius. (C) The normalized DEP force component values at 200 kHz for the three stages. increasing applied field strength, was confirmed by this computational modeling approach [8, 12]. One additional experimentally observed effect was that the optimal frequency for inhibitory effect of TTFields is inversely related to cell size [7, 13], and increased cell volume is seen in almost all cell lines treated with TTFields . Again computational modeling predicted similar results, by repeating the simulations with dividing cells whose major radius ranges from 4 to 15 μm.
2006;68(2):181–90. 28. Vajrala V, Claycomb JR, Sanabria H, Miller JH. Effects of oscillatory electric fields on internal membranes: an analytical model. Biophys J. 2008;94(6):2043–52. 29. Tiwari PK, Kang SK, Kim GJ, Choi J, Mohamed A-AH, Lee JK. Modeling of nanoparticlemediated electric field enhancement inside biological cells exposed to AC electric fields. Jpn J Appl Phys. 2009;48(8):087001. 30. Kotnik T, Bobanović F, Miklavčič D. Sensitivity of transmembrane voltage induced by applied fields—a theoretical analysis.
Wenger C, Giladi M, Bomzon Z, Salvador R, Basser PJ, Miranda PC. Modeling Tumor Treating Fields (TTFields) application in single cells during metaphase and telophase. Engineering in Medicine and Biology Society (EMBC), 2015. 37th Annual International Conference of the IEEE, 2015. p. 6892–5. 13. Kirson ED, Dbalý V, Tovarys F, Vymazal J, Soustiel JF, Itzhaki A, et al. Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. Proc Natl Acad Sci U S A. 2007;104(24):10152–7.
Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields by Eric T. Wong