Download e-book for kindle: An introduction to toxicogenomics by Michael E. Burczynski

By Michael E. Burczynski

ISBN-10: 0849313341

ISBN-13: 9780849313349

Because the introduction of cDNA microarrays, oligonucleotide array expertise, and gene chip research, genomics has revolutionized the full box of biomedical study. A byproduct of this revolution, toxicogenomics is a fast-rising celebrity inside toxicological research. accumulating jointly top authors and scientists on the vanguard of the sphere, An advent to Toxicogenomics presents a entire evaluate of this new self-discipline. With a spotlight on toxicology, it introduces the elemental ideas of microarray/oligonucleotide array-based genomic research and explains the way it matches into the sphere of biomedical examine. those discussions offer an outline to the particular mechanics of the analyses themselves and supply insights on dealing with and quality controls. Then the publication beneficial properties an incredible part at the fundamentals of knowledge research and clustering equipment equivalent to genetic algorithms. ultimately, it covers the applying of expression profiling within the box of toxicology and addresses the 2 basic kinds of research intimately, with sections devoted to either mechanistic and predictive studies.Although toxicogenomics delivers quickly, effective recommendations and information-rich facts, a lot of its strength is still untapped. An advent to Toxicogenomics consolidates the strategies underlying the sector to supply a fantastic starting place from which to start your examine endeavors.

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41. nl (Operon). 1,2 Since that time, gene expression microarray techniques have continued to be developed by many investigators who have recognized the unprecedented potential of array © 2003 by CRC Press LLC techniques for investigating many biological systems. In such a dynamic field of inquiry, it is not surprising that many of the basic techniques are still evolving, and the utility of specific microarrayrelated methods is greatly debated. However, if there is one point that most practitioners agree upon, it is that the quality of current microarray data is not guaranteed.

2. 3. 4. The majority of the authors’ experience has been with the Affymetrix GeneChip™ oligonucleotide array platform (Affymetrix; Santa Clara, CA). For this reason, most of this chapter describes QC methods that can be applied directly to this platform. Nevertheless, we stress that the concepts described later can, and should, be applied to other common platforms. Briefly, Affymetrix GeneChip® arrays typically consist of ~500,000 distinct 25-mer oligonucleotides, synthesized by photolithography on a glass substrate.

J. , Gene chips and arrays revealed: a primer on their power and their uses, Biol. , 45, 533, 1999. 32. N. , The bioinformatics of microarray gene expression profiling, Cytometry, 47, 46, 2002. 33. Yue, H. , 29, E41, 2001. 34. Yuen, T. , 30, e48, 2002. 35. A. , 3, SOFTWARE0001, 2002. 36. com (Affymetrix). 37. com (BD Clontech). 38. com (IncyteGenomics). 39. com/lifesciences (Motorola Life Sciences). 40. com (MWG Biotech). 41. nl (Operon). 1,2 Since that time, gene expression microarray techniques have continued to be developed by many investigators who have recognized the unprecedented potential of array © 2003 by CRC Press LLC techniques for investigating many biological systems.

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