Download PDF by C. Gad Shayne: Animal Models in Toxicology 2nd Edition (Drug and Chemical

By C. Gad Shayne

ISBN-10: 0824754077

ISBN-13: 9780824754075

Reflecting greater than a decade’s worthy of adjustments, Animal versions in Toxicology, moment version is a pragmatic consultant to the typical statistical difficulties encountered in toxicology and the methodologies which are on hand to resolve them. The booklet offers a ancient evaluation of using animal versions and an outline of extensive concerns of metabolism and relevance utilized in toxicology. person chapters masking the 8 significant species utilized in toxicology and experimental biology shape the middle of the ebook. With contributions from specialists in toxicology, toxicological pathology, and species-specific metabolism, each one of those chapters offer a good introductory “course” besides information to the literature for extra certain knowing. The booklet is going directly to make the case for a number species now not standard for security review experiences yet that can supply necessary substitute types for a few particular endpoints. The bankruptcy authors talk about detailed issues relating to theevaluation and interpretation of the scientific pathology of the 8 significant version species in addition to the right way to opt for a version species and the way to extrapolate the implications to people. They aspect strength pitfalls and events that reason both human or version to be considerably extra delicate than the opposite or absolutely inappropriate to one another. The publication concludes with an outline of the more and more advanced legislation and laws that govern how laboratory animals are bought, maintained, and applied, and an appendix that gives a brief consultant to advertisement assets of laboratory animals.

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Cytochrome P-450 dependent monooxygenase activity in nasal membranes. Drug Metab. Dispos. 11, 275–276. , and Vainio, H. (1973). Interspecies variations in small intestinal and hepatic drug hydroxylation and glucuronidation. Acta Pharmacol. Toxicol. 33, 57–64. , and Vainio, H. (1976). Effect of administration route on DDT acute toxicity and on drug biotransformation in various rodents. Arch. Environ. Contam. Toxicol. 4, 201–216. , and Kalant, H. (1972). The metabolism of ethanol and its metabolic effects.

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V. (2001). Guide to cytochrome P450. Philadelphia: Taylor & Francis. , and Bryan, G. (1973). Enzymatic N-acetylation of carcinogenic aromatic amines by liver cytosol of species displaying different oran susceptibilities. Biochem. Pharmacol. 22, 1581–1588. , and Gram, T. (1975). Comparison of in vitro drug metabolism by lung, liver, and kidney of several common laboratory species. Drug Metab. Dispos. 3, 259–265. Mandel, H. (1972). Pathways of drug biotransformation: Biochemical conjugation. In Fundamentals of drug metabolism and drug disposition, eds.

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Animal Models in Toxicology 2nd Edition (Drug and Chemical Toxicology) by C. Gad Shayne


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