New PDF release: Annual Review of Medicine Volume 59 2008

By C. Thomas Ed Caskey

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Extra info for Annual Review of Medicine Volume 59 2008

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Shaw AW, Pureza VS, Sligar SG, et al. 2007. The local phospholipid environment modulates the activation of blood clotting. J. Biol. Chem. 282:6556–63 9. Zhang J, Piro O, Lu L, Broze GJ Jr. 2003. Glycosyl phosphatidylinositol anchorage of tissue factor pathway inhibitor. org • TF-FVII Pathway and Therapeutic Opportunities 1. Contains many references. 6. One of the most recent extensive reviews; includes many references. 39 Annu. Rev. Med. 59:29-41. org by Kennesaw State University on 10/06/08. For personal use only.

The enhancement of thrombin generation on platelet surfaces by rFVIIa leads to a further activation of platelets (increased exposure of phospholipids) at the site of injury. It also increases platelet adhesion, suggested to involve an enhanced platelet-platelet interaction initiated by thrombin binding to GPIb as well as other mechanisms. Also, platelets from patients with Glanzmann’s thrombasthenia, deficient of GPIIb/IIIa, aggregated in the presence of rFVIIa under flow conditions using a collagen-coated surface; such aggregation may contribute to the effect of rFVIIa in Glanzmann’s thrombasthenia.

59:29-41. org by Kennesaw State University on 10/06/08. For personal use only. ANRV334-ME59-03 ARI 16 December 2007 14:39 29. Tranholm M, Kristensen K, Kristensen AT, et al. 2003. Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A. Blood 102:3615–20 30. Nordfang O, Valentin S, Beck T, et al. 1991. Inhibition of extrinsic pathway inhibitor shortens the coagulation time of normal plasma and of hemophilia plasma. Thromb. Hemost. 66:464–67 31. Erhardtsen E, Ezban M, Madsen MT, et al.

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Annual Review of Medicine Volume 59 2008 by C. Thomas Ed Caskey


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