By C. Thomas Ed Caskey
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Extra info for Annual Review of Medicine Volume 59 2008
Shaw AW, Pureza VS, Sligar SG, et al. 2007. The local phospholipid environment modulates the activation of blood clotting. J. Biol. Chem. 282:6556–63 9. Zhang J, Piro O, Lu L, Broze GJ Jr. 2003. Glycosyl phosphatidylinositol anchorage of tissue factor pathway inhibitor. org • TF-FVII Pathway and Therapeutic Opportunities 1. Contains many references. 6. One of the most recent extensive reviews; includes many references. 39 Annu. Rev. Med. 59:29-41. org by Kennesaw State University on 10/06/08. For personal use only.
The enhancement of thrombin generation on platelet surfaces by rFVIIa leads to a further activation of platelets (increased exposure of phospholipids) at the site of injury. It also increases platelet adhesion, suggested to involve an enhanced platelet-platelet interaction initiated by thrombin binding to GPIb as well as other mechanisms. Also, platelets from patients with Glanzmann’s thrombasthenia, deﬁcient of GPIIb/IIIa, aggregated in the presence of rFVIIa under ﬂow conditions using a collagen-coated surface; such aggregation may contribute to the effect of rFVIIa in Glanzmann’s thrombasthenia.
59:29-41. org by Kennesaw State University on 10/06/08. For personal use only. ANRV334-ME59-03 ARI 16 December 2007 14:39 29. Tranholm M, Kristensen K, Kristensen AT, et al. 2003. Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A. Blood 102:3615–20 30. Nordfang O, Valentin S, Beck T, et al. 1991. Inhibition of extrinsic pathway inhibitor shortens the coagulation time of normal plasma and of hemophilia plasma. Thromb. Hemost. 66:464–67 31. Erhardtsen E, Ezban M, Madsen MT, et al.
Annual Review of Medicine Volume 59 2008 by C. Thomas Ed Caskey