Antibacterial Agents: Chemistry, Mode of Action, Mechanisms - download pdf or read online

By Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley

ISBN-10: 0470972440

ISBN-13: 9780470972441

Antibacterial brokers act opposed to bacterial an infection both by means of killing the bacterium or by means of arresting its development. They do that by means of focusing on bacterial DNA and its linked procedures, attacking bacterial metabolic tactics together with protein synthesis, or interfering with bacterial mobilephone wall synthesis and function.

Antibacterial Agents is a necessary advisor to this significant type of chemotherapeutic medicines. Compounds are organised based on their goal, which is helping the reader comprehend the mechanism of motion of those medicinal drugs and the way resistance can come up. The booklet makes use of an built-in “lab-to-clinic” method which covers drug discovery, resource or synthesis, mode of motion, mechanisms of resistance, scientific elements (including hyperlinks to present instructions, major drug interactions, cautions and contraindications), prodrugs and destiny improvements.

Agents lined include:

  • agents focusing on DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents
  • agents focusing on metabolic techniques -  sulfonamide antibacterial brokers and trimethoprim
  • agents focusing on protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
  • agents focusing on cellphone wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin

Antibacterial Agents will discover a position at the bookshelves of scholars of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

Show description

Read or Download Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications PDF

Best clinical chemistry books

New PDF release: A Clinician's Handbook of Child and Adolescent Psychiatry

Offering a finished assessment of the most issues encountered through baby and adolescent psychiatrists in medical perform, this authoritative scientific instruction manual levels from consuming, sleep and affective problems to substance abuse, gender identification and sexual abuse. The procedure is evidence-based and emphasis is on sturdy scientific perform and quality controls of sufferer care.

Download e-book for iPad: Design of Caspase Inhibitors as Potential Clinical Agents by Tom O'Brien, Steven D. Linton

Provides the healing power for Caspase Inhibitors: current and destiny Caspases characterize the most particular protease households defined so far. those very important enzymes are an important to the destruction of aberrant cells – the body’s self-protection mechanism for fending off the expansion of irregular cells, a lot of which may advertise melanoma.

Producing Biomolecular Substances with Fermenters, - download pdf or read online

Containing authoritative and in-depth assurance, generating Biomolecular fabrics utilizing Fermenters, Bioreactors, and Biomolecular Synthesizers examines the bioproduction platforms that aid the managed, computerized, and volume progress of proteins. The ebook discusses the substance, personality, make-up, and caliber of the fundamental fabrics utilized in the construction and downstream processing of boimolecular fabrics: uncooked fabrics, reagents, intermediates, and consumables.

Extra resources for Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

Example text

Chang, D. M. Sievert, J. C. Hageman, M. L. Boulton, F. C. Tenover, F. P. Downes, S. Shah, J. T. Rudrik, G. R. Pupp, W. J. Brown, D. Cardo, and S. K. Fridkin, New Engl. J. , 2003, 348, 1342–1347. R. H. Ebright, J. Mol. , 2000, 304, 687–698. M. E. Falagas and I. A. Bliziotis, Intn. J. Antimicrob. Agents, 2007, 29, 630–636. L. S. Filho, J. L. Kuti, and D. P. Nicolau, Braz. J. , 2007, 38, 183–193. H. G. Floss and T. W. Yu, Chem. , 2005, 105, 621–632. P. W. Groundwater, A. Todd, A. J. Worsley, and R.

D. S. hospitals and the benefits of prevention (Publication No. CS200891-A). pdf, last accesssed 8 March 2012). A. Stadelmaier, S. Morath, T. Hartung, and R. R. Schmidt, Angew. Chem. Int. , 2003, 42, 916–920. T. A. , Mol. Cell. , 2008, 9, 242–253. F. C. Tenover, Clin. Infect. , 2007, 44, 418–423. M. Tumbarello, R. Citton, T. Spanu, M. Sanguinetti, L. Romano, G. Fadda, and R. Cauda, J. Antimicrob. , 2004, 53, 277. J. Turnidge, Aust. Prescriber, 2001, 24, 26–27. J. van Heijenoort, Nat. Prod. , 2001, 18, 503–519.

As mentioned in the previous subsection, and as we will see throughout this textbook, bacteria have remarkable ability to develop resistance to the antibacterial agents with which they are treated. In addition, humans have been very complacent with the use of antibiotics, believing that there was a never-ending supply of antibacterial agents. g. between 1992 and 1997, 56% of all antibiotics employed annually in Australia were used in feedstock). Avoparcin, a vancomycin analogue, was used as a growth promoter in pig feedstock, but was withdrawn from the market when a link was discovered between its use and the emergence of Enterococcus faecium expressing the vanA gene.

Download PDF sample

Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications by Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley

by Christopher

Rated 4.86 of 5 – based on 41 votes