By M. Holzenberger, E. Gay, S. Doublier, M. Binoux (auth.), Prof. Eugenio E. Müller (eds.)
In the previous couple of years, significant cognizance has been paid to the presence of insulin-like progress components (IGFs) and their binding proteins (IGF-BPs) within the mind and peripheral neuronal tissue. IGFs are synthesized in the CNS, are absolute to particular IGF-BPs and act on particular receptors. They characterize a brand new category of progress elements and messengers within the mind and the outer edge. Written by means of a gaggle of exceptional specialists within the box, the e-book presents a useful discussion board the place very important elements of the creation, legislation, organic activities, pathophysiological involvement, healing purposes for IGFs in lots of neurologic and neuromuscular problems are addressed and seriously evaluated.
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Extra resources for IGFs in the Nervous System
72. 73. 74. 75. 76. 77. 78. 79. 80. 43 like growth factors I and II: autoradiographic localization in rat brain and comparison to receptors for insulin. Endocrinology 123 (4):2089-2099 Araujo DM, Lapchak PA, Collier B, Chabot J-G, Quirion R (1989) Insulin-like growth factor-l (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system. Brain Res 484:130-138 De Meyts P, Wallach B, Christoffersen CT, Urso B, Gronskov K, Latus L-J, Yakushiji F, Hondo MM, Shymko RM (1994) The insulin-like growth factor-I receptor.
The distinct developmental pattern of IGF expression in the nervous system supports the hypothesis that IGF stimulates neuronal and glial cell growth. In the central nervous system, IGF increases myelin production [45-47], stimulates DNA synthesis  and induces a catecholaminergic phenotype in chick neural crest cells . Transgenic mice overexpressing IGF-I demonstrate increased brain size due to both increased neuronal size and number as well as increased myelination [50-52]. The biological actions of the IGFs are mediated by the type I IGF receptor (IGF-IR), a tyrosine kinase receptor.
Proc Nat! Acad Sci USA 93:8318-8323 Hernandez-Sanchez C, Werner H, Roberts CTI et al (1997) Differential regulation of insulin-like growth factor (IGF-I) receptor gene expression by IGF-I and basic fibroblast growth factor. I Bioi Chern 272:4663-4670 IGF-I in Neuronal Differentiation and Neuroprotedion Introduction Insulin-like growth factors I and II (IGF-I and IGF-II) are peptide growth factors structurally related to insulin [1,2]. Both IGF-I and IGF-II exert mitogenic and metabolic effects and influence differentiation in many cell types [3-6].
IGFs in the Nervous System by M. Holzenberger, E. Gay, S. Doublier, M. Binoux (auth.), Prof. Eugenio E. Müller (eds.)